Orexin Neurons Are Directly and Indirectly Regulated by Catecholamines in a Complex Manner
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چکیده
منابع مشابه
Title: Orexin Neurons Are Directly and Indirectly Regulated by Catecholamines in a Complex Manner
We previously reported that orexin neurons are directly hyperpolarized by noradrenaline (NA) and dopamine. In the present study, we show that NA, dopamine and adrenaline all directly hyperpolarized orexin neurons. This response was inhibited by the α2 adrenergic receptor (α2-AR) antagonist, idazoxan or BRL44408, and was mimicked by the α2-AR selective agonist, UK14304. A low concentration of Ba...
متن کاملOrexin neurons are directly and indirectly regulated by catecholamines in a complex manner.
We reported elsewhere that orexin neurons are directly hyperpolarized by noradrenaline (NA) and dopamine. In the present study, we show that NA, dopamine, and adrenaline all directly hyperpolarized orexin neurons. This response was inhibited by the alpha2 adrenergic receptor (alpha2-AR) antagonist, idazoxan or BRL44408, and was mimicked by the alpha2-AR-selective agonist, UK14304. A low concent...
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Orexin neurons (hypocretin neurons) have a critical role in the regulation of sleep/wakefulness, especially in the maintenance of arousal. Here, we revealed that orexin neurons are directly and indirectly activated by orexin via the orexin 2 receptor (OX2R). Orexin B (1 μM) induced depolarization in orexin neurons, which was still observed in the presence of TTX (1 μM), AP-5 (50 μM), and CNQX (...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2006
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.01361.2005